The 2006 Patriot League Women's Lacrosse Championship will be held at College of the Holy Cross, Hart Recreation Center. Competition will take place on Saturday, April 29 and Sunday, April 30. The tournament field will be made up of the top four teams. Patriot League women's lacrosse participation includes: American, Bucknell, Colgate, Holy Cross, Lafayette, Lehigh and associate member Villanova.
The winner of the 2006 Patriot League Women's Lacrosse Championship will move on to the NCAA Play-In game on Saturday, May 6 against the MAAC Champion.
| Saturday, April 29 |
| No. 1 Holy Cross 13, No. 4 Bucknell 7 | Box Score | Recap |
| No. 2 Colgate 12, No. 3 American 7 | Box Score | Recap |
| Sunday, April 30 |
| No. 1 Holy Cross 9, No. 2 Colgate 6 | Box Score | Recap |